

Oncology
Sensible Biotherapeutics Oncology Research
Sensible Biotherapeutics, LLC is currently targeting medulloblastoma and glioblastoma as opportunities for innovation and therapy. In this regard, there is a unique gene discovered by Dr. Meyer that is very heavily expressed in high grade gliomas but hardly at all in normal brain tissue.
This gene is intimately involved with a key cellular function (the specifics of which are confidential). The histochemical localization the protein shows vastly different results for high grade gliomas versus normal brain tissue; the contrast between the two is impressive. For example, a figure is provided on the right that shows the distinct differences.
Sensible Biotherapeutics has designed an antisense Oligonucleotide to potentially prevent expression of this protein and has formed a confidentiality agreement (NDA) with a top US-based university to exchange ideas and perhaps pursue further research into this protein, and recently identified a potential target identified within medulloblastoma.


Normal Brain High-grade Glioma
Source for images: https://www.proteinatlas.org/